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CBD E-Liquids: Separating Fact From Fiction

I had a few misconceptions about CBD prior to trying it. A friend of mine was vaping it across from me, and after innocently asking what their e-liquid was, my curiosity was piqued.

“So does it give you a sort of relaxed, sleepy high?” I asked, “Like weed but just with the body high?”

She explained that it helped her with stress and anxiety but didn’t really give any sort of “high.” I knew CBD e-liquid was legal – or at least, I thought I did because I’d seen it for sale – but other than that I didn’t know much at all.

After some research online, I found many other people claiming similar benefits to my friend. Surprisingly, there were also a few stories – like that of Charlotte Figi – that seemed to attest to some benefits for serious health problems, and there was some hard evidence to back it up too. I’d tried a few puffs of her vape pen, but the more I learned, the more I was interested to give it a proper go for myself.

But finding reliable information about CBD isn’t easy. Even answering seemingly simple questions like “Is CBD legal?” is surprisingly difficult, and the wealth of information on what it is and what it does quickly gets complicated.

So, what is CBD? What’s in CBD e-liquid? Can you vape CBD oil in a normal vape pen? Are the claimed medical benefits really backed up by science? Will you get in trouble with the law if you try to buy it?

I took a closer look to bring you the real facts behind CBD e-liquids and what you might be vaping.



What is CBD? 

CBD is short for cannabidiol.

You’re probably familiar with it as one of the many compounds found in the cannabis plant.

The most well-known compound in the cannabis plant is THC (delta-9 tetrahydrocannabinol), which is responsible for most of the psychoactive effects of cannabis. THC is just one of over 80 cannabinoids found in the cannabis plant. CBD is the next most abundant chemical in the most commonly-used strains of cannabis. Other cannabinoids include cannabinol, cannibichromene and cannabigerol.

A cannabinoid is just a name for a chemical which interacts with the cannabinoid receptors in your body. Your body even makes its own cannabinoids, called “endocannabinoids,” with anandamide (sometimes called the “bliss molecule”) being the most famous example. In contrast to endocannabinoids, those made by plants are called “phytocannabinoids,” and this includes CBD and THC.

Each individual cannabinoid has different effects, and the amounts of each present in cannabis varies with each specific strain of the plant. Increasing the amount of THC is the biggest concern for recreational use, but for medical use, high-CBD strains are very common. However, much of the CBD for sale these days is grown from industrial hemp, which tends to have substantial amounts of CBD with only miniscule amounts of THC. 


Does CBD or CBD oil get you high?

In short, no.

As one of the non-psychoactive compounds found in cannabis plant, CBD is unable to get you high; as we’ve pointed out, the psychoactive component that people feel is THC.

The reason for this is a little bit complicated and relates to how CBD interacts with the main receptors in your body’s endocannabinoid system. The short version is that while THC directly interacts with the main receptors (called CB1 and CB2), CBD’s effects appear to be indirect, which impacts how they function without directly stimulating them. CBD also seems to increase the levels of the natural endocannabinoids in your body, because it impairs the enzyme which ordinarily breaks them down.

The simple answer is still that CBD is not psychoactive and won’t get you “high,” but getting high is most definitely not the goal of using CBD.

So, why (and how) would you vape it?


The Medical Benefits of CBD Liquid

Let’s talk about the potential medical benefits of CBD first, which has become an increasing focus for studies and trials.


- Reducing Seizures 

The potential medical benefits of CBD gained a lot of attention through the story of Charlotte Figi. Charlotte suffers from a type of epilepsy called Dravet syndrome, and at the worst, her condition meant that she suffered from a staggering 300 seizures per week. Her doctors had tried everything, and her parents were at their wits end. In desperation, her parents decided to try CBD oil as an alternative treatment.

This decision would ultimately change Charlotte’s life. Her seizures dropped dramatically, down to just one per day. This massive, life-changing improvement was documented by CNN medical correspondent (who became something of an accidental advocate for medicinal cannabis) Sanjay Gupta and brought a lot of attention to CBD treatment in the media. There is even a high-CBD strain of cannabis named after her, “Charlotte’s Web.”

As compelling as Charlotte’s story is, we all know that anecdotes aren’t the same as hard scientific evidence. Thankfully, there has been more objective research into CBD’s potential to reduce seizures.

So does CBD really work for seizures? In 2014, researchers reviewed the available evidence and concluded that there wasn’t enough data to draw a firm conclusion on whether it’s useful. However, that was three years ago, and studies conducted since then have offered some cause for optimism. One example study looked at the efficacy of CBD in 137 patients with severe, treatment-resistant epilepsy. It found that the median number of motor seizures dropped from 30 per month to about 16 after three months of treatment.

Another study from Israel followed very similar methods, and found that 89% of 74 patients reported less frequent seizures following treatment. Around 52% had half the number of seizures or even fewer on CBD treatment. Similar results were obtained from a study conducted at the University of Alabama, where about half of patients responded positively after 6 months.

Finally, a 2017 study looked at Dravet syndrome (the type Charlotte Figi suffers from), using a randomized controlled trial design in 120 children and young adults. This is higher-quality evidence than the other studies mentioned above (which weren’t placebo-controlled), but the results were similar: the median number of convulsive seizures reduced from 12.4 to 5.9 over a 14-week treatment period. However, side effects such as vomiting, diarrhoea, fatigue, fever and drowsiness were much more common in the group treated with CBD.

If you’re confused, you’re not alone. But this is typical when it comes to the evidence on CBD. It’s hard to study because of issues surrounding legality, and the research tends to have small numbers of participants and isn’t always high quality. However, the results for treatment-resistant seizure disorders are pretty promising.

In general, CBD seems to work despite some side effects. With this in mind, even though more evidence is needed, the FDA has allowed “compassionate use” of CBD (specifically GW Pharmaceuticals’ CBD product, Epidiolex) at some epilepsy centres in the US. 


- Anxiety

Although most of the interest in CBD’s medical benefits is focused towards reducing seizures, most people considering vaping CBD e-liquid won’t be using it to reduce seizures. Anxiety is a much more common issue which may be helped by CBD, and there is a little bit of evidence on the topic we can take a look at to see if it’s likely to work.

Overall, the evidence from animal and human studies suggests that CBD does have benefits for anxiety. One example study looked at the effect of CBD in 12 generalised social anxiety disorder sufferers, while 12 others were given a placebo. The study revolved around a simulated public speaking task, and found that CBD treatment was effective at reducing anxiety in people undergoing the task, compared to the placebo group.

Again, the evidence here isn’t rock-solid, but on the whole it seems that using CBD for anxiety could be a valuable approach. 


- Pain Management

Another reason you may be considering using CBD for medical purposes is for the management of pain. Studies suggest that THC – the psychoactive component of cannabis – is useful for pain when combined with CBD, but overall it seems like THC is mainly responsible for the effects. However, there is some other evidence that CBD is good for neuropathic (nerve) pain and pain related to inflammation.

Without THC, it’s unlikely to replace your pain medication unless you have specific types of pain, but there is some potential for CBD and pain. It’s worth trying provided you confer with your doctor about your options and the role CBD could play in your treatment. However, if you live somewhere where cannabis is legal for medical or recreational purposes, it’s probably better to use a combination of THC and CBD to treat pain (again, pending advice from your doctor).


Other Conditions

There are many other conditions people claim will be helped by CBD. In general – and as you might expect given the studies we’ve looked at so far – there isn’t too much evidence to recommend CBD in other cases, although there are positive signs. For example, there is some evidence that CBD could be an effective treatment for general psychoses and schizophrenia, and evidence from animal and cell models suggest that CBD could have positive effects on diabetes, the heart and blood vessels and even cancer.

However, it’s crucial to note that these are areas of ongoing research and we’re far from establishing that these results translate into positive effects in the real world. Cell studies and animal models don’t tell you enough to determine whether or not a treatment would be effective or even wise in real humans.


Is CBD E-liquid Legal?

You would be wise to double-check the legality of CBD where you live before you consider purchasing it. Keep in mind that even where CBD is legal, products which also contain THC probably aren’t.

The UK: Legal for use both recreational and medical, providing products only contain CBD, not THC. The MHRA released a statement in 2016 noting that vendors have to pull their products from the shelves or comply with regulations set out in the Human Medicines Regulations 2012 by December.

According to the statement, “MHRA will now work with individual companies and trade bodies in relation to making sure products containing CBD, used for a medical purpose, which can be classified as medicines, satisfy the legal requirements of the Human Medicines Regulations 2012.”

For CBD products that don’t make medical claims (they’re often sold as food supplements), there shouldn’t be an issue. However, the legal situation is a little confusing. While CBD isn’t explicitly outlawed, it’s rarely addressed at all in law, and in cases where there are even traces of THC (which will be most cases) it could be argued that the finished CBD product is banned under the same rules that apply to cannabis (the 1971 Misuse of Drugs Act).

People often cite EU regulations to say that products with less than 0.2 % THC are permitted, but unfortunately the rules actually relate to hemp rather than CBD. If – in theory – you had an issue, you could claim you didn’t know there was THC in there, but then the legal arguments get a little complicated.

However, the cannabis law reform group CLEARLY argues that CBD is absolutely legal provided the seller doesn’t make medical claims, although they don’t address the potential issue of trace amounts of THC. Regardless of the nuances, it’s safe to say that enforcement of any particular law pertaining to CBD is not a priority.

In conclusion, CBD-products are generally considered legal in the UK, providing:

  • They don’t contain any THC
  • They have a licence IF advertised for medical benefits.

The USA: A High Times article explains the legal status of CBD in the US in detail, but unfortunately there is little clarity across the pond either. The problem there revolves around the definition of “marijuana” (which uses this now-antiquated spelling) in US federal law, which basically includes any part of the cannabis plant or any extract that can contain substantial amounts of cannabinoids. Many people selling and defending CBD oil cite various laws to claim it’s always legal, but – much like the UK – this often depends on misinterpretations of the complex legal reality.

The federal stance on CBD is summed up by the following quote:

Therefore, if there exists a cannabis plant, regardless of its THC content, anywhere it is grown, the DEA considers it “marihuana,” unless it was a hemp plant grown by a university or state agriculture department. Whatever you extract from a hemp plant is “marihuana,” except what you extract from stalks and seeds, which the DEA says couldn’t possibly be CBD, unless that came from resin sticking to the stalks and seeds, and all resin from anywhere on any cannabis plant is “marihuana”.

In a nutshell: not all parts of hemp or marijuana plants are illegal, but all of the parts you can actually get CBD or other cannabinoids from are.

Unfortunately, there is no short answer to the question of the legality of CBD in the US. The best advice is to check your state laws, although chances are, you won’t run into issues if you use or possess CBD.

India: Cannabis and its derivatives – including CBD – are considered an illegal substance in India; some allowances are made for registered shops selling bhang, a traditional cannabis drink.

Australia: Just like everywhere else, the law surrounding CBD in Australia is a little confusing. According to the Australian Hemp Party, cannabidiol “in preparations for therapeutic use containing 2% or less of other cannabinoids” is classed as schedule 4. Based on this, depending on where you find yourself in Australia, you should be able to find CBD products legally, though you might need a prescription first. Hemp-derived CBD oil used to be sold for “external use only” as a sort of loophole (where stores claimed it wasn’t to be ingested but knew full well people did ingest it), but now hemp oil has been legalised for human consumption. This should make it much easier to find legal CBD oil in Australia, provided it is extremely low in THC.


The Science Behind Vaping CBD

The first in-depth study on CBD and vaping appeared in 2015, carrying the word-heavy title: A protocol for the delivery of cannabidiol (CBD) and combined CBD and ∆9tetrahydrocannabinol (THC) by vaporisation.

For the study, “Purified THC and CBD (40 mg/ml and 100 mg/ml respectively) were loaded onto a liquid absorbing pad in a Volcano® vaporiser, vaporised and the vapours quantitatively analysed”.

Preliminary results found that the highest dose effectively vaporized is 200 mg of CBD heated to a temperature of 230°C / 446 °F. Most cannabis vaporizers can operate at this temperature, although it may be at the upper end of the available range.


What Are the Side Effects of CBD?

The side-effects on CBD have been studied, too. A 2011 study noted that “chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.” Side-effects – if any – might include:

  1. Inhibition of the metabolism of drugs by the liver2. What people generally known as “cottonmouth” – a sensation of dry mouth, which is due to the cannabinoid receptors found in the saliva glands.
  2. Low blood pressure and lightheadedness. CBD is known to cause reductions in blood pressure, and while this could potentially be a positive effect (for people with cardiovascular issues), it could also cause problems if you already have low blood pressure. It can also lead to light-headedness.
  3. At higher doses, the effects of CBD can lead to drowsiness. If you have this issue, the best advice is to reduce your dosage of CBD.

According to the 2011 study, CBD doesn’t cause changes in food intake (also called “the munchies,” common with THC), doesn’t cause disruptions in body temperature or heart rate and does not affect psychomotor functions in any way.


CBD Oil Vs. CBD E-Liquid

There’s a huge range of THC and CBD-based products out there. CBD oil with coconut oil bases are popular, as are ones using hemp oil as a base, but you’ll also run into CBD e-liquid. It gets confusing – especially to a newcomer.


What’s the difference and can you vape them?

CBD E-Liquid: Like regular e-liquid, CBD e-liquid is primarily composed of propylene glycol (PG), vegetable glycerine (VG), food flavourings (technically optional, but very common) and the active ingredient, which in this case is CBD rather than nicotine.

As all vapers know, PG/VG mixtures can be used in a vape pen or mod without issues. The CBD in many of these products comes from CBD “isolate,” which is a purified form of CBD that contains no other components, although some are “full spectrum” extractions that include other cannabinoids (not including THC, which is definitively illegal).

CBD Oils: As the name suggests, CBD oil is CBD diluted in an oil, rather than the alcohols (PG and VG) used in most e-liquids. This is often hemp oil, but other types of oil such as coconut oil can also be used for CBD oil. These require specialised devices to be used in order to effectively vape them.

There are many cannabis vaporizers that support oil or concentrate vaping, but if you’re hoping to vape using an ordinary e-cigarette, you’ll need CBD e-liquid instead of CBD oil. And that’s before we get onto the potential health concerns related to inhaling oils… 


Buying CBD Oil and E-Liquids

So if you’re interested in trying CBD vaping, where should you go? What type of device should you get?

Plenty of options are available on the market: In most cases, you can walk into your nearest vape shop or head online and find hundreds of options. 

There are several UK and US-based companies which offer CBD e-liquid, and many which offer oils too. The main thing to look for is the ingredients used in the product. For example, some suppliers use coconut oil as their carrier, and others use hemp seed oil. These oil-based products carry a potential risk of lipoid pneumonia if inhaled, but you can consume they by adding them to food or simply dropping some under your tongue.

If you’re looking for CBD e-liquid to vape, there are many companies that mix CBD with PG and/or VG so they can be vaped in ordinary devices. Bradley's CBD is a good example of such a company, offering lemon and lime CBD e-juice and mixed berry, all available with either 125, 250 or 500 mg of CBD in a 30 ml bottle. Unlike with traditional e-liquid, where the nicotine level is shown per ml, in CBD e-liquid, the value shown is usually the total content of the bottle. In the example above, 125 mg would be 4.2 mg/ml, and 250 mg would be 8.30 mg/ml.

When using CBD oil or e-liquid exclusively for health reasons – physical or mental – you’ll also want to run this information by your doctor and find out what they think about its use for your condition.

Be aware that in some areas where CBD-products are legal, products containing trace amounts of THC might not be legal under the same law. Again: Check with your state, check with others, and check with your doctor. 


The real thing and nothing but...

Always make sure that the products you buy are high-quality, pure-CBD. Just like when you’re shopping for an e-liquid, it’s best to opt for companies that offer test results to ensure you’re getting what you pay for. For CBD e-liquids, test results will usually show the content of CBD and other cannabinoids in the mix, and often also list the quantities of various “terpenes” (which provide the characteristic aroma of cannabis) and show the absence of contaminants.

Looking for lab tests and checking the results is a reliable way to make sure you’re getting pure CBD. You should still check customer reviews and ideally check out lab test results, but this is a good way to save time and effort if you want to find a reliable company without needing to do as much leg-work.


Is Hemp-Derived CBD as Good as Cannabis-Derived CBD?

There is a lot of dispute within the CBD community about the benefits of hemp-derived CBD vs. CBD obtained from high-CBD strains of cannabis. Many claim that hemp-derived CBD is lower quality and won’t be as pure or high in CBD compared to that taken from cannabis. However, CBD is CBD, no matter where it comes from.

If you buy a CBD e-liquid with 20 mg/ml of CBD, it makes precisely zero difference where that CBD came from, provided both products have lab tests confirming that they’re accurately labelled and free from contaminants.

Some people argue that because more hemp has to be processed to produce the same amount of CBD compared to high-CBD marijuana, then the “bio-accumulation” of pesticides or chemicals from soil could impact the quality of the product. Again, lab results are very valuable when it comes to making a decision based on this, and reputable companies go to a lot of effort to produce a pure product from either source.

More importantly, from a practical perspective, hemp-derived CBD is cheaper to produce and much less likely to contain legally suspect quantities of THC. In short, while you could certainly argue that CBD derived from ordinary cannabis plants is likely to be safer than hemp-derived CBD, the differences aren’t likely to be significant, and hemp-derived CBD is both easier to find and cheaper.


Vaping Safety: Can You Vape CBD Oil in an E-Cig?

Now, let’s talk about what you can’t use in an ordinary electronic cigarette: CBD oil. 

And that’s not just because of legal reasons.Your standard e-cig or vape mod (as opposed to vaporisers specifically designed for use with CBD oil) is not designed to handle this oil, and it’s likely to damage or clog your e-cig.

That doesn’t mean that you can’t vape CBD oil, but most people who do use cannabis vaporizers, which are not to be confused with e-cigs. These are often designed to handle “dry herb” (i.e. hemp in the form of plant matter) which has been finely ground up, but some devices can support oils or waxes too. If you have CBD oil (rather than e-liquid) you can use a device suitable for “concentrates” if you do want to vape it.

If you’re going to vape cannabis oil or even CBD oil, you should ensure your device is capable of supporting it. Using thick oils or concentrates in an ordinary e-cigarette is a guaranteed way to damage your coil. Our personal recommendation would be to avoid vaping oils at all, particularly over the long-term risk of lipoid pneumonia – but ultimately the decision is up to you.


Will it show up on a drug test?

Do you have a job which involves drug tests? These tests are a growing concern for many professionals who fear they might face the axe at work after a puff of CBD vape juice.

Drug tests will not show a positive result for CBD, simply because drug tests are testing for the psychoactive component in cannabis (i.e. THC) and not CBD.

You should be fine when vaping pure CBD-oil. Still, If in doubt, it’s probably better to avoid or, if you urgently need a solution for a medical condition, check with your employer first.

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